RegenExtracell BMC®
The Flexible & Reproducible Bone Marrow Concentrate SystemWhat is RegenExtracell BMC ?
BONE MARROW CONCENTRATE (BMC) IS AN AUTOLOGOUS CELL CONCENTRATE FROM BONE MARROW ASPIRATE.
Bone marrow is a liquid tissue rich in a heterogeneous population of mature cells and multipotent stem cells. Among them, the mesenchymal stromal cells (MSC) are the musculoskeletal tissue precursor cells.
These tubes contain a biologically inert separating gel with a specific density that stabilises the physical separation of plasma and mononuclear cell (MNC) fractions from the other cellular elements of the bone marrow aspirate. This allows intraoperative processing of bone marrow aspirate to produce a bone marrow aspirate concentrate that is reimplanted during the same surgical procedure without the need for cell selection and expansion in the laboratory (‘one-step therapy’) (Holton et al., 2016).
More than 80 % of the MSCs are obtained in the resulting cell concentrate. In vitro, these cells form colony-forming fibroblast units (CFU-F), which are capable of undergoing osteogenesis, chondrogenesis and adipogenesis when cultured in their respective specific induction medium. By transferring all the regenerative potential in the bone marrow aspirate to the site of the lesion, the bone marrow aspirate concentrate represents an interesting therapeutic option for treatment.
Since 2003, Regen Lab SA has been committed to the development of a unique expertise for the design and manufacturing of high-quality medical devices, intended for cells therapies.