RegenPRP®
the platelet concentrate prepared with RegenLab® technology provides an autologous reservoir of growth factors.What is RegenPRP® ?
1.1 – Platelets
In addition to their role in haemostasis, are key factors in tissue repair mechanisms.1 They provide essential growth factors, such as FGF, PDGF, TGF-β, EGF, VEGF, IGF, which are involved in stem cell migration, differentiation and proliferation. Platelet growth factors also stimulate fibroblasts and endothelial cells to induce the deposition of new extracellular matrix and neo-vascularisation, respectively.
1.2 – Plasma
Contains many factors essential for cell survival including nutrients, vitamins, hormones, electrolytes, growth factors (such as IGF and HGF), and proteins. Among the plasma proteins, the molecules vital for the coagulation process and for formation of the fibrin polymer will serve as a scaffold for cell migration and new tissue generation.2
1.3 – Platelet Rich Plasma (PRP)
- Proven role in the healing of tissues, with key roles in cell migration, proliferation and differentiation
- Mechanism of action comprises anti-inflammatory activity and activation of cell-signalling cascades
- Key role in the synthesis of new extracellular matrix for tissue regeneration
1.4 – RegenKit® Technology
The RegenKit®-BCT are medical devices intended for the preparation of RegenPRP®. They contain Regen BCT tubes. Regen BCT tubes are made of pharmaceutical grade glass with a vacuum for automated blood collection. They contain a sodium citrate anticoagulant solution and a separator gel to separate plasma and platelets from the blood cells and produce RegenPRP® with a standardised composition.
Technology advantages
- User-independent standardised preparation
- Minimum volume of blood required
- Safe closed-circuit system
- Mechanical separation of PRP using a chemically inert separator gel after 5-minute centrifugation at 1500g
- Pharmaceutical grade solution of sodium citrate allowing a reversible anticoagulation
- Minimal learning curve and ease of use
- Operationally and clinically efficient process
- Facilitates and streamlines routine practice
Biological advantages
- RegenPRP® is standardised, leucocyte-reduced, and easily reproducible with RegenLab®’s specific separator gel technology, ensuring minimal variability
- Platelet recovery > 80%
- High platelet quality. Viable & functional
- Full plasma recovery. No loss of plasma growth factors and fibrinogen
- Leucocyte-reduced PRP. Depletion of pro-inflammatory granulocytes, leaving mainly lymphocytes and monocytes
- Virtually no red blood cells.
Scientific advantages
- Demonstrated safety and efficacy
- Evidence-based outcomes for numerous therapeutic indications
- Clinical studies, with over 200 publications
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